Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

Summary: Understanding the root causes of autoimmune diseases is hampered by the inability to access relevant human tissues and identify the time of disease onset. To examine the interaction of immune cells and their cellular targets in type 1 diabetes, we differentiated human induced pluripotent st...

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Bibliographic Details
Main Authors: Nayara C. Leite, Elad Sintov, Torsten B. Meissner, Michael A. Brehm, Dale L. Greiner, David M. Harlan, Douglas A. Melton
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Cell Reports
Subjects:
type 1 diabetes
induced pluripotent stem cell-derived β cells
disease modeling
endoplasmic reticulum stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308755

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