Single-cell RNA sequencing of equine mesenchymal stromal cells from primary donor-matched tissue sources reveals functional heterogeneity in immune modulation and cell motility

Single-cell RNA sequencing of equine mesenchymal stromal cells from primary donor-matched tissue sources reveals functional heterogeneity in immune modulation and cell motility

Abstract Background The efficacy of mesenchymal stromal cell (MSC) therapy is thought to depend on the intrinsic heterogeneity of MSC cultures isolated from different tissue sources as well as individual MSCs isolated from the same tissue source, neither of which is well understood. To study this, w...

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Bibliographic Details
Main Authors: Rebecca M. Harman, Roosheel S. Patel, Jennifer C. Fan, Jee E. Park, Brad R. Rosenberg, Gerlinde R. Van de Walle
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stromal cells
Single-cell RNA sequencing
Heterogeneity
Immune modulation
Cell motility
Online Access:https://doi.org/10.1186/s13287-020-02043-5

Internet

https://doi.org/10.1186/s13287-020-02043-5

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