Context-Dependent Effect of Glucocorticoids on the Proliferation, Differentiation, and Apoptosis of Regulatory T Cells: A Review of the Empirical Evidence and Clinical Applications

Context-Dependent Effect of Glucocorticoids on the Proliferation, Differentiation, and Apoptosis of Regulatory T Cells: A Review of the Empirical Evidence and Clinical Applications

Glucocorticoids (GCs) are widely used to treat several diseases because of their powerful anti-inflammatory and immunomodulatory effects on immune cells and non-lymphoid tissues. The effects of GCs on T cells are the most relevant in this regard. In this review, we analyze how GCs modulate the survi...

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Bibliographic Details
Main Authors: Luigi Cari, Francesca De Rosa, Giuseppe Nocentini, Carlo Riccardi
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
glucocorticoids
regulatory T (Treg) cells
peripherally derived Treg (pTreg) cells
thymus-derived Treg cells (tTreg)
Treg cell number modulation
human autoimmune diseases
human allergic diseases
desensitizing treatment
tolerogenic response
Online Access:http://www.mdpi.com/1422-0067/20/5/1142

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