Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.

Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.

We report a preclinical study of a pyrrole-imidazole (PI) polyamide that targets the human transforming growth factor (hTGF)-β1 gene as a novel transcriptional gene silencer in a common marmoset primate model. We designed and then synthesized PI polyamides to target the hTGF-β1 promoter. We examined...

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Bibliographic Details
Main Authors: Jun Igarashi, Noboru Fukuda, Takashi Inoue, Shigeki Nakai, Kosuke Saito, Kyoko Fujiwara, Hiroyuki Matsuda, Takahiro Ueno, Yoshiaki Matsumoto, Takayoshi Watanabe, Hiroki Nagase, Toshikazu Bando, Hiroshi Sugiyama, Toshio Itoh, Masayoshi Soma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4418757?pdf=render

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