Hypertonic Saline Suppresses NADPH Oxidase-Dependent Neutrophil Extracellular Trap Formation and Promotes Apoptosis

Hypertonic Saline Suppresses NADPH Oxidase-Dependent Neutrophil Extracellular Trap Formation and Promotes Apoptosis

Tonicity of saline (NaCl) is important in regulating cellular functions and homeostasis. Hypertonic saline is administered to treat many inflammatory diseases, including cystic fibrosis. Excess neutrophil extracellular trap (NET) formation, or NETosis, is associated with many pathological conditions...

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Bibliographic Details
Main Authors:	Ajantha Nadesalingam, Jacky H. K. Chen, Armin Farahvash, Meraj A. Khan
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-03-01
Series:	Frontiers in Immunology
Subjects:	hypertonic saline NaCl neutrophil extracellular traps NOX2-dependent NETosis lipopolysaccharide-induced NETosis Gram-negative and -positive bacteria-induced NETosis
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00359/full

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