Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells.

Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells.

Anthracycline daunorubicin (DNR) is one of the major antitumor agents widely used in the treatment of myeloid leukemia. Unfortunately, the clinical efficacy of DNR was limited because of its cytotoxity at high dosage. As a novel cytoprotective mechanism for tumor cell to survive under unfavorable co...

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Bibliographic Details
Main Authors: Weidong Han, Jie Sun, Lifeng Feng, KaiFeng Wang, Da Li, Qin Pan, Yan Chen, Wei Jin, Xian Wang, Hongming Pan, Hongchuan Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3229606?pdf=render

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