SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA

SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA

Abstract Steroid receptor RNA activator 1 (SRA1) has been described as a novel transcriptional co-activator that affects the migration of cancer cells. Through RT-PCR, we identified that skipping exon 3 of SRA1 produces two isoforms, including the truncated short isoform, SRA1-S, and the long isofor...

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Main Authors: Sijia Lei, Bin Zhang, Luyuan Huang, Ziyou Zheng, Shaohan Xie, Lianghua Shen, Mason Breitzig, Alexander Czachor, Hongtao Liu, Huiru Luo, Yanxia Chen, Kangshou Liu, Hanxiao Sun, Qing Zheng, Qiang Li, Feng Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00498-w

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