Ornithine Aminotransferase, an Important Glutamate-Metabolizing Enzyme at the Crossroads of Multiple Metabolic Pathways

Ornithine δ-aminotransferase (OAT, E.C. 2.6.1.13) catalyzes the transfer of the δ-amino group from ornithine (Orn) to α-ketoglutarate (aKG), yielding glutamate-5-semialdehyde and glutamate (Glu), and vice versa. In mammals, OAT is a mitochondrial enzyme, mainly located in the liver, intestine, brain...

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Bibliographic Details
Main Authors: Antonin Ginguay, Luc Cynober, Emmanuel Curis, Ioannis Nicolis
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Biology
Subjects:
Online Access:http://www.mdpi.com/2079-7737/6/1/18