Characterization of dermal skin innervation in fibromyalgia syndrome.
INTRODUCTION:We characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology. METHODS:Skin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene produ...
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doaj-ce5520d7065140e9acb465f29eefbb702021-03-03T21:25:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01151e022767410.1371/journal.pone.0227674Characterization of dermal skin innervation in fibromyalgia syndrome.Dimitar EvdokimovPhiline DinkelJohanna FrankClaudia SommerNurcan ÜçeylerINTRODUCTION:We characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology. METHODS:Skin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene product 9.5, calcitonine gene-related peptide, substance P, CD31, and neurofilament 200 for small fiber subtypes. We assessed two skin sections per patient; on each skin section, two dermal areas (150 x 700 μm each) were investigated for dermal nerve fiber length (DNFL). RESULTS:In FMS patients we found reduced DNFL of fibers with vessel contact compared to healthy controls (p<0.05). There were no differences for the other nerve fiber subtypes. DISCUSSION:We found less dermal nerve fibers in contact with blood vessels in FMS patients than in controls. The pathophysiological relevance of this finding is unclear, but we suggest the possibility of a relationship with impaired thermal tolerance commonly reported by FMS patients.https://doi.org/10.1371/journal.pone.0227674 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dimitar Evdokimov Philine Dinkel Johanna Frank Claudia Sommer Nurcan Üçeyler |
spellingShingle |
Dimitar Evdokimov Philine Dinkel Johanna Frank Claudia Sommer Nurcan Üçeyler Characterization of dermal skin innervation in fibromyalgia syndrome. PLoS ONE |
author_facet |
Dimitar Evdokimov Philine Dinkel Johanna Frank Claudia Sommer Nurcan Üçeyler |
author_sort |
Dimitar Evdokimov |
title |
Characterization of dermal skin innervation in fibromyalgia syndrome. |
title_short |
Characterization of dermal skin innervation in fibromyalgia syndrome. |
title_full |
Characterization of dermal skin innervation in fibromyalgia syndrome. |
title_fullStr |
Characterization of dermal skin innervation in fibromyalgia syndrome. |
title_full_unstemmed |
Characterization of dermal skin innervation in fibromyalgia syndrome. |
title_sort |
characterization of dermal skin innervation in fibromyalgia syndrome. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2020-01-01 |
description |
INTRODUCTION:We characterized dermal innervation in patients with fibromyalgia syndrome (FMS) as potential contribution to small fiber pathology. METHODS:Skin biopsies of the calf were collected (86 FMS patients, 35 healthy controls). Skin was immunoreacted with antibodies against protein gene product 9.5, calcitonine gene-related peptide, substance P, CD31, and neurofilament 200 for small fiber subtypes. We assessed two skin sections per patient; on each skin section, two dermal areas (150 x 700 μm each) were investigated for dermal nerve fiber length (DNFL). RESULTS:In FMS patients we found reduced DNFL of fibers with vessel contact compared to healthy controls (p<0.05). There were no differences for the other nerve fiber subtypes. DISCUSSION:We found less dermal nerve fibers in contact with blood vessels in FMS patients than in controls. The pathophysiological relevance of this finding is unclear, but we suggest the possibility of a relationship with impaired thermal tolerance commonly reported by FMS patients. |
url |
https://doi.org/10.1371/journal.pone.0227674 |
work_keys_str_mv |
AT dimitarevdokimov characterizationofdermalskininnervationinfibromyalgiasyndrome AT philinedinkel characterizationofdermalskininnervationinfibromyalgiasyndrome AT johannafrank characterizationofdermalskininnervationinfibromyalgiasyndrome AT claudiasommer characterizationofdermalskininnervationinfibromyalgiasyndrome AT nurcanuceyler characterizationofdermalskininnervationinfibromyalgiasyndrome |
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