Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview...

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Main Authors:	Che C. Colpitts, Pei-Ling Tsai, Mirjam B. Zeisel
Format:	Article
Language:	English
Published:	MDPI AG 2020-03-01
Series:	International Journal of Molecular Sciences
Subjects:	hepatitis c virus viral entry endocytosis fusion cell-to-cell transmission hepatocyte
Online Access:	https://www.mdpi.com/1422-0067/21/6/2091

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spelling	doaj-ce54a0fad7c04960b66b4e5a051ec2032020-11-25T02:01:59ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-03-01216209110.3390/ijms21062091ijms21062091Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated ProcessChe C. Colpitts0Pei-Ling Tsai1Mirjam B. Zeisel2Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, CanadaCancer Research Center of Lyon (CRCL), UMR Inserm 1052 CNRS 5286 Mixte CLB, Université de Lyon 1 (UCBL1), 69003 Lyon, FranceHepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors.https://www.mdpi.com/1422-0067/21/6/2091hepatitis c virusviral entryendocytosisfusioncell-to-cell transmissionhepatocyte
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Che C. Colpitts Pei-Ling Tsai Mirjam B. Zeisel
spellingShingle	Che C. Colpitts Pei-Ling Tsai Mirjam B. Zeisel Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process International Journal of Molecular Sciences hepatitis c virus viral entry endocytosis fusion cell-to-cell transmission hepatocyte
author_facet	Che C. Colpitts Pei-Ling Tsai Mirjam B. Zeisel
author_sort	Che C. Colpitts
title	Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title_short	Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title_full	Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title_fullStr	Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title_full_unstemmed	Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process
title_sort	hepatitis c virus entry: an intriguingly complex and highly regulated process
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2020-03-01
description	Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver disease worldwide. Its tissue and species tropism are largely defined by the viral entry process that is required for subsequent productive viral infection and establishment of chronic infection. This review provides an overview of the viral and host factors involved in HCV entry into hepatocytes, summarizes our understanding of the molecular mechanisms governing this process and highlights the therapeutic potential of host-targeting entry inhibitors.
topic	hepatitis c virus viral entry endocytosis fusion cell-to-cell transmission hepatocyte
url	https://www.mdpi.com/1422-0067/21/6/2091
work_keys_str_mv	AT checcolpitts hepatitiscvirusentryanintriguinglycomplexandhighlyregulatedprocess AT peilingtsai hepatitiscvirusentryanintriguinglycomplexandhighlyregulatedprocess AT mirjambzeisel hepatitiscvirusentryanintriguinglycomplexandhighlyregulatedprocess
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Hepatitis C Virus Entry: An Intriguingly Complex and Highly Regulated Process

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