Impact of the level of testosterone on the development of cancer of the prostate
Androgen blockade has been widely used in the treatment of. prostatic cancer (PC) for more than 60 years. However, most patients develop high-grade androgen-resistant PC a few years after the initiation of hormonal therapy. This study was undertaken to explore the mechanisms of this process. Fourtee...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2020-02-01
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| Series: | Onkourologiâ |
| Online Access: | https://oncourology.abvpress.ru/oncur/article/view/1198 |
| Summary: | Androgen blockade has been widely used in the treatment of. prostatic cancer (PC) for more than 60 years. However, most patients develop high-grade androgen-resistant PC a few years after the initiation of hormonal therapy. This study was undertaken to explore the mechanisms of this process. Fourteen patients with Stages 3-4 PC were followed up. They all underwent orchiectomy. Comparison of the data obtained before and 1 month has shown than the decreased level of testosterone enhances mitotic activity, impairs the regulation of a cell cycle, and induces apoptosis, while its significantly lowered level causes antitumor immunity decompensation. |
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| ISSN: | 1726-9776 1996-1812 |