A CASE REPORT OF AN ULTRA-RAPID METABOLIZER ON DEPOT FORMULATIONS OF RISPERIDONE AND HALOPERIDOL AND REFLECTIONS ON METABOLIC PATHWAYS

A CASE REPORT OF AN ULTRA-RAPID METABOLIZER ON DEPOT FORMULATIONS OF RISPERIDONE AND HALOPERIDOL AND REFLECTIONS ON METABOLIC PATHWAYS

Polycyclic aromatic hydrocarbons (PAH) in tobacco are potent inducers of Cytochrome P450 (CYP) 1A2, which metabolizes a plenty of drugs including antipsychotics such as olanzapine or clozapine. With regard to haloperidol and risperidone, CYP3A4 is supposed to be the major isoenzyme. We present the c...

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Bibliographic Details
Main Authors: Horst Koch, Heike Zellmer, Eva-Gabriele Steinbach
Format: Article
Language:English
Published: University in Nis, Faculty of Medicine 2014-09-01
Series:Acta Medica Medianae
Subjects:
risperidone
haloperidol
ultra-rapid metabolisation
tobacco
CYP3A4
schizophrenia
Online Access:http://publisher.medfak.ni.ac.rs/2014-html/3-broj/Koch%20Horst%20-Case%20report.pdf

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