A CASE REPORT OF AN ULTRA-RAPID METABOLIZER ON DEPOT FORMULATIONS OF RISPERIDONE AND HALOPERIDOL AND REFLECTIONS ON METABOLIC PATHWAYS

A CASE REPORT OF AN ULTRA-RAPID METABOLIZER ON DEPOT FORMULATIONS OF RISPERIDONE AND HALOPERIDOL AND REFLECTIONS ON METABOLIC PATHWAYS

Polycyclic aromatic hydrocarbons (PAH) in tobacco are potent inducers of Cytochrome P450 (CYP) 1A2, which metabolizes a plenty of drugs including antipsychotics such as olanzapine or clozapine. With regard to haloperidol and risperidone, CYP3A4 is supposed to be the major isoenzyme. We present the c...

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Bibliographic Details
Main Authors: Horst Koch, Heike Zellmer, Eva-Gabriele Steinbach
Format: Article
Language:English
Published: University in Nis, Faculty of Medicine 2014-09-01
Series:Acta Medica Medianae
Subjects:
risperidone
haloperidol
ultra-rapid metabolisation
tobacco
CYP3A4
schizophrenia
Online Access:http://publisher.medfak.ni.ac.rs/2014-html/3-broj/Koch%20Horst%20-Case%20report.pdf
Description
Summary:Polycyclic aromatic hydrocarbons (PAH) in tobacco are potent inducers of Cytochrome P450 (CYP) 1A2, which metabolizes a plenty of drugs including antipsychotics such as olanzapine or clozapine. With regard to haloperidol and risperidone, CYP3A4 is supposed to be the major isoenzyme. We present the case of a 60-year old woman who suffered from chronic schizophrenia and smoked more than 40 cigarettes per day, which indicates that PAH also induces CYP3A4, causing ultrarapid metabolisation of risperidone and haloperidol with subtherapeutic drug levels both after oral or intramuscular depot administration.
ISSN:0365-4478
1821-2794

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