Suppression of Harmaline Tremor by Activation of an Extrasynaptic GABAA Receptor: Implications for Essential Tremor

Suppression of Harmaline Tremor by Activation of an Extrasynaptic GABAA Receptor: Implications for Essential Tremor

Background: Metabolic imaging has revealed excessive cerebellar activity in essential tremor patients. Golgi cells control cerebellar activity by releasing gamma-aminobutyric acid (GABA) onto synaptic and extrasynaptic receptors on cerebellar granule cells. We postulated that the extrasynaptic GABAA...

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Bibliographic Details
Main Authors: Adrian Handforth, Pournima A. Kadam, Hovsep P. Kosoyan, Pirooz Eslami
Format: Article
Language:English
Published: Ubiquity Press 2018-06-01
Series:Tremor and Other Hyperkinetic Movements
Subjects:
Harmaline
GABA
Cerebellum
Tremor
Harmaline tremor
Essential tremor
Neurology
Gamma-aminobutyric acid
Online Access:https://tremorjournal.org/index.php/tremor/browse?&year=2018results=10&page=3

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