MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells

MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells

Abstract Background The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression. While much is known regarding MAPK/ERK signal conveyance from the cell membrane to the nucleus, the transcriptional and epige...

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Bibliographic Details
Main Authors: Temesgen D. Fufa, Laura L. Baxter, Julia C. Wedel, Derek E. Gildea, NISC Comparative Sequencing Program, Stacie K. Loftus, William J. Pavan
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Epigenetics & Chromatin
Subjects:
Pigmentation
Melanocyte
MAPK pathway
MEK inhibitor
Enhancers
SOX10
Online Access:http://link.springer.com/article/10.1186/s13072-019-0297-2

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