Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells

Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells

Abstract Background Leucine-rich alpha 2 glycoprotein (LRG) has been identified as a serum protein elevated in patients with active rheumatoid arthritis (RA). Although the function of LRG is ill-defined, LRG binds with transforming growth factor (TGF)-β and enhances Smad2 phosphorylation. Considerin...

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Bibliographic Details
Main Authors: Hayato Urushima, Minoru Fujimoto, Takashi Mishima, Tomoharu Ohkawara, Hiromi Honda, Hyun Lee, Hirohisa Kawahata, Satoshi Serada, Tetsuji Naka
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Arthritis Research & Therapy
Subjects:
Leucine rich alpha2 glycoprotein
TGF-β
Smad2
IL-6 receptor
Th17
Online Access:http://link.springer.com/article/10.1186/s13075-017-1349-2

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