Dissecting the Entry Route of Saporin-based a-CD7 Immunotoxins in Human T-Cell Acute Lymphoblastic Leukaemia Cells

Dissecting the Entry Route of Saporin-based a-CD7 Immunotoxins in Human T-Cell Acute Lymphoblastic Leukaemia Cells

Elucidating the intracellular fate(s) of targeted toxins is of fundamental importance for their optimal use as anticancer drugs, since the biochemical targets of their enzymatic activity reside in the cell cytoplasm, as in the case of the plant ribosome inactivating proteins (RIP) saporin, ricin and...

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Bibliographic Details
Main Authors: Maria Serena Fabbrini, Sopsamorn U. Flavell, David J. Flavell, Riccardo Vago, Valeria Giordani, Francesco Giansanti, Rodolfo Ippoliti
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Antibodies
Subjects:
endocytosis
immunotoxin
ricin
Brefeldin A
leukaemia cells
Online Access:http://www.mdpi.com/2073-4468/2/1/50

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