Ultradeep targeted sequencing reveals low allele frequencies of somatic JAK2 and MPL variants in patients with abdominal vein thromboses: results of an ongoing prospective prevalence study in Mecklenburg-West Pomerania

Ultradeep targeted sequencing reveals low allele frequencies of somatic JAK2 and MPL variants in patients with abdominal vein thromboses: results of an ongoing prospective prevalence study in Mecklenburg-West Pomerania

Abstract Myeloproliferative neoplasms are characterized by mutations in JAK2, MPL and CALR genes. Commonly in diagnostics and previous studies mainly sequencing and common PCR techniques under conventional detection limits are used. Splanchnic vein thromboses are rare, but often appear associated wi...

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Bibliographic Details
Main Authors: Luise Grunwald, Christina Grosse-Thie, Sina Sender, Gudrun Knuebel, Saskia Krohn, Catrin Roolf, Christian Junghanss, Larissa Henze, Hugo Murua Escobar
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Biomarker Research
Subjects:
Molecular genetics
Blood coagulation
Myeloproliferative neoplasms
Splanchnic vein thrombosis
Next generation sequencing
Ultradeep targeted sequencing
Online Access:https://doi.org/10.1186/s40364-020-00254-9

Internet

https://doi.org/10.1186/s40364-020-00254-9

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