Host PrP glycosylation: a major factor determining the outcome of prion infection.

Host PrP glycosylation: a major factor determining the outcome of prion infection.

The expression of the prion protein (PrP) is essential for transmissible spongiform encephalopathy (TSE) or prion diseases to occur, but the underlying mechanism of infection remains unresolved. To address the hypothesis that glycosylation of host PrP is a major factor influencing TSE infection, we...

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Bibliographic Details
Main Authors: Nadia L Tuzi, Enrico Cancellotti, Herbert Baybutt, Lorraine Blackford, Barry Bradford, Chris Plinston, Anne Coghill, Patricia Hart, Pedro Piccardo, Rona M Barron, Jean C Manson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2292751?pdf=render

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http://europepmc.org/articles/PMC2292751?pdf=render

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