Individual and Combined Treatments with Methylated Resveratrol Analogue DMU-214 and Gefitinib Inhibit Tongue Cancer Cells Growth via Apoptosis Induction and EGFR Inhibition

Individual and Combined Treatments with Methylated Resveratrol Analogue DMU-214 and Gefitinib Inhibit Tongue Cancer Cells Growth via Apoptosis Induction and EGFR Inhibition

The methylated resveratrol analogue 3′-hydroxy-3,4,5,4′-tetramethoxystilbene (DMU-214) has been revealed to exert the anti-cancer activity by a block of the cell cycle at the G2/M phase, apoptosis induction, and metastasis inhibition. These biological events may be involved in crosstalk with the epi...

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Bibliographic Details
Main Authors: Malgorzata Jozkowiak, Marta Dyszkiewicz-Konwinska, Piotr Ramlau, Wieslawa Kranc, Julia Spaczynska, Marcin Wierzchowski, Mariusz Kaczmarek, Jadwiga Jodynis-Liebert, Hanna Piotrowska-Kempisty
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
tongue cancer
resveratrol analogue
DMU-214
gefitinib
EGFR inhibitor
apoptosis
Online Access:https://www.mdpi.com/1422-0067/22/12/6180

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