miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms’ tumor

miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms’ tumor

Abstract Background Wilms’ tumor is also called nephroblastoma and is the most common pediatric renal cancer. Several genetic and epigenetic factors have been found to account for the development of Wilms’ tumor. MiRNAs play important roles in this tumorigenic process. In the present study, we aimed...

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Bibliographic Details
Main Authors: Zhuo Liu, Feng He, Shengrong OuYang, Yuanyuan Li, Feifei Ma, Huibo Chang, Dingding Cao, Jianxin Wu
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Cancer
Subjects:
Wilms’ tumor
miRNA-140-5p
IGF1R
TGFBRI
cell signaling
Online Access:http://link.springer.com/article/10.1186/s12885-019-5609-1

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http://link.springer.com/article/10.1186/s12885-019-5609-1

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