Harmine inhibits breast cancer cell migration and invasion by inducing the degradation of Twist1.

Harmine inhibits breast cancer cell migration and invasion by inducing the degradation of Twist1.

Breast cancer is the leading cause of cancer-related deaths in the United States. The majority of deaths (90%) in breast cancer patients is caused by invasion and metastasis-two features related to the epithelial-to-mesenchymal transition (EMT). Twist1 is a key transcription factor that promotes the...

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Bibliographic Details
Main Authors: Ebtesam Nafie, Jade Lolarga, Brandon Lam, Jonathan Guo, Elnaz Abdollahzadeh, Sandy Rodriguez, Carlotta Glackin, Junjun Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0247652

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https://doi.org/10.1371/journal.pone.0247652

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