Castleman’s Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up

A 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epst...

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Main Authors:	Lokesh K. Jha, Laura L. Ulmer, Marco A. Olivera-Martinez, Timothy M. McCashland, Kai Fu, Fedja A. Rochling
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Case Reports in Hepatology
Online Access:	http://dx.doi.org/10.1155/2018/9324872

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spelling	doaj-cde140e0f09d49379fda6bfb6155466c2020-11-24T20:47:27ZengHindawi LimitedCase Reports in Hepatology2090-65872090-65952018-01-01201810.1155/2018/93248729324872Castleman’s Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-UpLokesh K. Jha0Laura L. Ulmer1Marco A. Olivera-Martinez2Timothy M. McCashland3Kai Fu4Fedja A. Rochling5Division of Gastroenterology & Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USADivision of Gastroenterology & Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USADivision of Gastroenterology & Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USADivision of Gastroenterology & Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USADepartment of Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE, USADivision of Gastroenterology & Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USAA 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epstein-Barr virus (EBV) DNA. Lymph node biopsy for lymphadenopathy on imaging showed human herpes virus 8 (HHV8) associated Castleman’s disease. Treatment included valganciclovir, rituximab, and prednisone taper with eventual discontinuation. Quantitative HHV8 DNA was initially 611,000 DNA copies/mL and was later undetectable at 6 months following treatment and remained undetectable at 3-year follow-up.http://dx.doi.org/10.1155/2018/9324872
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Lokesh K. Jha Laura L. Ulmer Marco A. Olivera-Martinez Timothy M. McCashland Kai Fu Fedja A. Rochling
spellingShingle	Lokesh K. Jha Laura L. Ulmer Marco A. Olivera-Martinez Timothy M. McCashland Kai Fu Fedja A. Rochling Castleman’s Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up Case Reports in Hepatology
author_facet	Lokesh K. Jha Laura L. Ulmer Marco A. Olivera-Martinez Timothy M. McCashland Kai Fu Fedja A. Rochling
author_sort	Lokesh K. Jha
title	Castleman’s Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title_short	Castleman’s Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title_full	Castleman’s Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title_fullStr	Castleman’s Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title_full_unstemmed	Castleman’s Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up
title_sort	castleman’s disease and posttransplant lymphoproliferative disorder after liver transplant: 3-year follow-up
publisher	Hindawi Limited
series	Case Reports in Hepatology
issn	2090-6587 2090-6595
publishDate	2018-01-01
description	A 59-year-old male with a history of hepatitis C cirrhosis and history of hepatitis B exposure presented 8 months after orthotopic liver transplant (LT) with fever, fatigue, myalgia, night sweats, nonproductive cough, and shortness of breath. Bone marrow biopsy for pancytopenia was positive for Epstein-Barr virus (EBV) DNA. Lymph node biopsy for lymphadenopathy on imaging showed human herpes virus 8 (HHV8) associated Castleman’s disease. Treatment included valganciclovir, rituximab, and prednisone taper with eventual discontinuation. Quantitative HHV8 DNA was initially 611,000 DNA copies/mL and was later undetectable at 6 months following treatment and remained undetectable at 3-year follow-up.
url	http://dx.doi.org/10.1155/2018/9324872
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Castleman’s Disease and Posttransplant Lymphoproliferative Disorder after Liver Transplant: 3-Year Follow-Up

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