RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis

RINT1 Loss Impairs Retinogenesis Through TRP53-Mediated Apoptosis

Genomic instability in the central nervous system (CNS) is associated with defective neurodevelopment and neurodegeneration. Congenital human syndromes that affect the CNS development originate from mutations in genes of the DNA damage response (DDR) pathways. RINT1 (Rad50-interacting protein 1) is...

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Bibliographic Details
Main Authors: Anielle L. Gomes, Gabriel E. Matos-Rodrigues, Pierre-Olivier Frappart, Rodrigo A. P. Martins
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DNA damage response
replicative stress
neurodegeneration
visual system development
neurogenesis
ganglion cells
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00711/full

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