MicroRNA-10a-3p Improves Cartilage Degeneration by Regulating CH25H-CYP7B1-RORα Mediated Cholesterol Metabolism in Knee Osteoarthritis Rats

MicroRNA-10a-3p Improves Cartilage Degeneration by Regulating CH25H-CYP7B1-RORα Mediated Cholesterol Metabolism in Knee Osteoarthritis Rats

Osteoarthritis (OA) is a worldwide degenerative joint disease that seriously impaired the quality of life of patients. OA has been established as a disease with metabolic disorder. Cholesterol 25-hydroxylase (CH25H) was proved to play a key role in cartilage cholesterol metabolism. However, the biol...

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Bibliographic Details
Main Authors: Xiaochen Li, Li Zhang, Xiaoqing Shi, Taiyang Liao, Nongshan Zhang, Yifan Gao, Runlin Xing, Peimin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
osteoarthritis
cartilage degeneration
miR-10a-3p
cholesterol metabloism
CH25H
CYP7B1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.690181/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.690181/full

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