Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug

Glycyrrhetinic Acid-Poly(ethylene glycol)-glycyrrhetinic Acid Tri-Block Conjugates Based Self-Assembled Micelles for Hepatic Targeted Delivery of Poorly Water Soluble Drug

The triblock 18β-glycyrrhetinic acid-poly(ethylene glycol)-18β-glycyrrhetinic acid conjugates (GA-PEG-GA) based self-assembled micelles were synthesized and characterized by FTIR, NMR, transmission electron microscopy, and particle size analysis. The GA-PEG-GA conjugates having the critical micelle...

Full description

Bibliographic Details
Main Authors:	Fengbo Wu, Ting Xu, Chi Liu, Can Chen, Xiangrong Song, Yu Zheng, Gu He
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1155/2013/913654

Similar Items

Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma
by: Dun Fan, et al.
Published: (2018-01-01)

Synthesis and Anticancer Activities of Glycyrrhetinic Acid Derivatives
by: Yang Li, et al.
Published: (2016-02-01)

Glycyrrhetinic acid and its derivatives in infectious diseases
by: Langer Dominik, et al.
Published: (2016-09-01)

Metabolic Engineering for Glycyrrhetinic Acid Production in Saccharomyces cerevisiae
by: Ruobing Guan, et al.
Published: (2020-11-01)

The Aggravation of Clozapine-Induced Hepatotoxicity by Glycyrrhetinic Acid in Rats
by: Ling-ling Jia, et al.
Published: (2014-01-01)

In vitro and in vivo protein release and anti-ischemia/reperfusion injury properties of bone morphogenetic protein-2-loaded glycyrrhetinic acid-poly(ethylene glycol)-b-poly(L-lysine) nanoparticles
by: Shan F, et al.
Published: (2017-10-01)

EMBRYOTOXIC AND TERATOGENIC EFFECT OF DISODIUM GLYCYRRHETINIC ACID HEMIPHTHALATE IN MICE
by: H. Marzbnn
Published: (1998-07-01)

Mechanism and Improved Dissolution of Glycyrrhetinic Acid Solid Dispersion by Alkalizers
by: Luning Dong, et al.
Published: (2020-01-01)

EMBRYOTOXIC AND TERATOGENIC EFFECT OF DISODIUM GLYCYRRHETINIC ACID HEMIPHTHALATE IN MICE
by: H. Marzbnn
Published: (1998-06-01)

Antibacterial Effects of Glycyrrhetinic Acid and Its Derivatives on Staphylococcus aureus.
by: Kentaro Oyama, et al.
Published: (2016-01-01)

Design and preparation of derivatives of oleanolic and glycyrrhetinic acids with cytotoxic properties
by: Wang R, et al.
Published: (2018-05-01)

Inhibitory Effects of Glycyrrhetinic Acid on DNA Polymerase and Inflammatory Activities
by: Tsukasa Ishida, et al.
Published: (2012-01-01)

Synthesis and Antiproliferative Activity of Novel Heterocyclic Glycyrrhetinic Acid Derivatives
by: Daniela P. S. Alho, et al.
Published: (2019-02-01)

Glycyrrhetinic Acid Antagonizes Pressure-Induced Venous Remodeling in Mice
by: Hanna Kuk, et al.
Published: (2018-04-01)

Glycyrrhetinic Acid Maintains Intestinal Homeostasis via HuR
by: Gang Chen, et al.
Published: (2019-05-01)

Phytochemical studies on Buxus macowanii and microbial transformation of glycyrrhetinic acid
by: Lam, Cheuk Wing
Published: (2012)

Phytochemical studies on Buxus macowanii and microbial transformation of glycyrrhetinic acid
by: Lam, Cheuk Wing
Published: (2012)

The effect of 18β-Glycyrrhetinic acid derivative in skin physiology
by: Wen-Hao Hsieh, et al.
Published: (2010)

Efficient synthesis of piperazinyl amides of 18β-glycyrrhetinic acid
by: Dong Cai, et al.
Published: (2020-04-01)

Emodin-glycyrrhetinic acid-β-cyclodextrin inclusion complex for liver targeting
by: Yi-Ting Hou, et al.
Published: (2018)

Exploring the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Glycyrrhizic and Glycyrrhetinic Acids
by: Seidu A. Richard
Published: (2021-01-01)

Specific binding and characteristics of 18β-glycyrrhetinic acid in rat brain.
by: Kazushige Mizoguchi, et al.
Published: (2014-01-01)

Suppressive Effects of Glycyrrhetinic Acid Derivatives on Tachykinin Receptor Activation and Hyperalgesia
by: Yuko Akasaka, et al.
Published: (2011-01-01)

The Effect of Glycyrrhetinic Acid on Pharmacokinetics of Cortisone and Its Metabolite Cortisol in Rats
by: Dan Lin, et al.
Published: (2012-01-01)

Synthesis and biological activity of new 18β-glycyrrhetinic acid derivatives
by: Mohamed O. Radwan, et al.
Published: (2016-05-01)

1,2,5-Oxadiazolo[3,4-b]glycyrrhetinic acid
by: Jun Hu, et al.
Published: (2009-07-01)

An experimental in-vitro study to evaluate the anti-helicobacter activity of Glycyrrhetinic acid
by: Celik Muhammet Murat, et al.
Published: (2019-01-01)

Observations on the effects of cortico-steroids and of glycyrrhetinic acid on salt and water metabolism
by: Galal, E. E.
Published: (1954)

Glycyrrhizin Acid and Glycyrrhetinic Acid Modified Polyethyleneimine for Targeted DNA Delivery to Hepatocellular Carcinoma
by: Mingzhuo Cao, et al.
Published: (2019-10-01)

Photo Irradiation-Induced Core Crosslinked Poly(ethylene glycol)-block-poly(aspartic acid) Micelles: Optimization of Block Copolymer Synthesis and Characterization of Core Crosslinked Micelles
by: Kouichi Shiraishi, et al.
Published: (2017-12-01)

Differential induction of isolated lymphoid follicles in the gut by 18β-glycyrrhetinic acid.
by: Jay M Hendricks, et al.
Published: (2014-01-01)

Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics
by: Cheng M, et al.
Published: (2014-01-01)

Synthesis and Antiproliferative Activity of Novel A-Ring Cleaved Glycyrrhetinic Acid Derivatives
by: Daniela P.S. Alho, et al.
Published: (2019-08-01)

Co‐delivery of docetaxel and retinoic acid by poly (ethylene glycol)‐retinoic acid conjugates based micelles for synergistic prostate cancer therapy
by: Hang Hu, et al.
Published: (2021-05-01)

Solubility Ratios, Encapsulation Efficiency, and Size of Beta-sitosterol Loaded Poly(Lactide)-Block-Poly(Ethylene glycol) Polymeric Micelles
by: Alqarni, Ali
Published: (2019)

In vitro effects of glycyrrhetinic acid and hyaluronic acid on the growth of vulvovaginal Candida albicans and other yeasts
by: Martina Stevan, et al.
Published: (2017-12-01)

The Study of Polymeric Micelles Based on Folate-Poly(ethylene glycol)-Poly(L-lactic acid) and Methoxy Poly(ethylene glycol)-Poly(L-lactide) Copolymer
by: Ling Lee, et al.
Published: (2006)

Polymeric micelles from poly(ethylene glycol-co-sebacic acid) diblock copolymer
by: 簡國航
Published: (2005)

A novel drug delivery system of mixed micelles based on poly(ethylene glycol)‐poly(lactide) and poly(ethylene glycol)‐poly(ɛ‐caprolactone) for gambogenic acid
by: Tong‐Yuan Lin, et al.
Published: (2019-12-01)

Efficient production of glycyrrhetinic acid in metabolically engineered Saccharomyces cerevisiae via an integrated strategy
by: Caixia Wang, et al.
Published: (2019-05-01)