EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia

EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia

Sensory hair cells develop an asymmetric architecture to restrict stimulus detection to a single axis. Here the authors identify GPR156 as directing a 180-degree reversal in hair cell orientation through Gαi, downstream of EMX2 in the mouse inner ear and zebrafish lateral line.

Bibliographic Details
Main Authors: Katie S. Kindt, Anil Akturk, Amandine Jarysta, Matthew Day, Alisha Beirl, Michaela Flonard, Basile Tarchini
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22997-1
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spelling doaj-cdb53b6108644c36ae6b163b74f2d6352021-05-23T11:13:39ZengNature Publishing GroupNature Communications2041-17232021-05-0112111910.1038/s41467-021-22997-1EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epitheliaKatie S. Kindt0Anil Akturk1Amandine Jarysta2Matthew Day3Alisha Beirl4Michaela Flonard5Basile Tarchini6Section on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthThe Jackson LaboratoryThe Jackson LaboratoryThe Jackson LaboratorySection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of HealthThe Jackson LaboratoryThe Jackson LaboratorySensory hair cells develop an asymmetric architecture to restrict stimulus detection to a single axis. Here the authors identify GPR156 as directing a 180-degree reversal in hair cell orientation through Gαi, downstream of EMX2 in the mouse inner ear and zebrafish lateral line.https://doi.org/10.1038/s41467-021-22997-1
collection DOAJ
language English
format Article
sources DOAJ
author Katie S. Kindt
Anil Akturk
Amandine Jarysta
Matthew Day
Alisha Beirl
Michaela Flonard
Basile Tarchini
spellingShingle Katie S. Kindt
Anil Akturk
Amandine Jarysta
Matthew Day
Alisha Beirl
Michaela Flonard
Basile Tarchini
EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia
Nature Communications
author_facet Katie S. Kindt
Anil Akturk
Amandine Jarysta
Matthew Day
Alisha Beirl
Michaela Flonard
Basile Tarchini
author_sort Katie S. Kindt
title EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia
title_short EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia
title_full EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia
title_fullStr EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia
title_full_unstemmed EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia
title_sort emx2-gpr156-gαi reverses hair cell orientation in mechanosensory epithelia
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-05-01
description Sensory hair cells develop an asymmetric architecture to restrict stimulus detection to a single axis. Here the authors identify GPR156 as directing a 180-degree reversal in hair cell orientation through Gαi, downstream of EMX2 in the mouse inner ear and zebrafish lateral line.
url https://doi.org/10.1038/s41467-021-22997-1
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AT anilakturk emx2gpr156gaireverseshaircellorientationinmechanosensoryepithelia
AT amandinejarysta emx2gpr156gaireverseshaircellorientationinmechanosensoryepithelia
AT matthewday emx2gpr156gaireverseshaircellorientationinmechanosensoryepithelia
AT alishabeirl emx2gpr156gaireverseshaircellorientationinmechanosensoryepithelia
AT michaelaflonard emx2gpr156gaireverseshaircellorientationinmechanosensoryepithelia
AT basiletarchini emx2gpr156gaireverseshaircellorientationinmechanosensoryepithelia
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