EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia

EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia

Sensory hair cells develop an asymmetric architecture to restrict stimulus detection to a single axis. Here the authors identify GPR156 as directing a 180-degree reversal in hair cell orientation through Gαi, downstream of EMX2 in the mouse inner ear and zebrafish lateral line.

Bibliographic Details
Main Authors: Katie S. Kindt, Anil Akturk, Amandine Jarysta, Matthew Day, Alisha Beirl, Michaela Flonard, Basile Tarchini
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22997-1
Description
Summary:Sensory hair cells develop an asymmetric architecture to restrict stimulus detection to a single axis. Here the authors identify GPR156 as directing a 180-degree reversal in hair cell orientation through Gαi, downstream of EMX2 in the mouse inner ear and zebrafish lateral line.
ISSN:2041-1723

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