Interbase-FRET binding assay for pre-microRNAs

Abstract The aberrant expression of microRNAs (miRs) has been linked to several human diseases. A promising approach for targeting these anomalies is the use of small-molecule inhibitors of miR biogenesis. These inhibitors have the potential to (i) dissect miR mechanisms of action, (ii) discover new...

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Bibliographic Details
Main Authors: Mattias Bood, Anna Wypijewska del Nogal, Jesper R. Nilsson, Fredrik Edfeldt, Anders Dahlén, Malin Lemurell, L. Marcus Wilhelmsson, Morten Grøtli
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-88922-0