The Sex-Determining Factors SRY and SOX9 Regulate Similar Target Genes and Promote Testis Cord Formation during Testicular Differentiation
Male sex determination is mediated sequentially by sex-determining region Y (SRY) and related SRY-box 9 (SOX9) transcription factors. To understand the gene regulatory hierarchy for SRY and SOX9, a series of chromatin immunoprecipitation and whole-genome promoter tiling microarray (ChIP-Chip) experi...
Main Authors: | Yunmin Li, Ming Zheng, Yun-Fai Chris Lau |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2014-08-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124714005579 |
Similar Items
-
Mutations in the testis-specific enhancer of SOX9 in the SRY independent sex-determining mechanism in the genus Tokudaia.
by: Ryutaro Kimura, et al.
Published: (2014-01-01) -
Sox9 : an SRY related gene involved in sex determination
by: Morais da Silva, Sara Luisa
Published: (1998) -
Global genome analysis of the downstream binding targets of testis determining factor SRY and SOX9.
by: Ramji K Bhandari, et al.
Published: (2012-01-01) -
Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations.
by: Kevin C Knower, et al.
Published: (2011-03-01) -
Testicular differentiation occurs in absence of R-spondin1 and Sox9 in mouse sex reversals.
by: Rowena Lavery, et al.
Published: (2012-01-01)