Low-energy electrons transform the nimorazole molecule into a radiosensitiser

Low-energy electrons transform the nimorazole molecule into a radiosensitiser

Radiosensitisers are believed to interfere with cancer cells by dissociating upon interaction with electrons. Here the authors observe instead that the dominant path for nitroimidazolic radiosensitisers involves formation of a non-dissociated radical anion, prerequisite for their accumulation in tum...

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Main Authors: Rebecca Meißner, Jaroslav Kočišek, Linda Feketeová, Juraj Fedor, Michal Fárník, Paulo Limão-Vieira, Eugen Illenberger, Stephan Denifl
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10340-8
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spelling doaj-cd9cad2156bb416a9e119dc7b675e27c2021-05-11T11:46:35ZengNature Publishing GroupNature Communications2041-17232019-06-011011710.1038/s41467-019-10340-8Low-energy electrons transform the nimorazole molecule into a radiosensitiserRebecca Meißner0Jaroslav Kočišek1Linda Feketeová2Juraj Fedor3Michal Fárník4Paulo Limão-Vieira5Eugen Illenberger6Stephan Denifl7Institut für Ionenphysik und Angewandte Physik and Center for Biomolecular Sciences Innsbruck, Leopold-Franzens Universität InnsbruckJ. Heyrovský Institute of Physical Chemistry v.v.i., The Czech Academy of SciencesUniversité de Lyon; Université Claude Bernard Lyon1; Institut de Physique Nucléaire de LyonJ. Heyrovský Institute of Physical Chemistry v.v.i., The Czech Academy of SciencesJ. Heyrovský Institute of Physical Chemistry v.v.i., The Czech Academy of SciencesAtomic and Molecular Collisions Laboratory, CEFITEC, Department of Physics, Universidade NOVA de LisboaInstitut für Ionenphysik und Angewandte Physik and Center for Biomolecular Sciences Innsbruck, Leopold-Franzens Universität InnsbruckInstitut für Ionenphysik und Angewandte Physik and Center for Biomolecular Sciences Innsbruck, Leopold-Franzens Universität InnsbruckRadiosensitisers are believed to interfere with cancer cells by dissociating upon interaction with electrons. Here the authors observe instead that the dominant path for nitroimidazolic radiosensitisers involves formation of a non-dissociated radical anion, prerequisite for their accumulation in tumour cells.https://doi.org/10.1038/s41467-019-10340-8
collection DOAJ
language English
format Article
sources DOAJ
author Rebecca Meißner
Jaroslav Kočišek
Linda Feketeová
Juraj Fedor
Michal Fárník
Paulo Limão-Vieira
Eugen Illenberger
Stephan Denifl
spellingShingle Rebecca Meißner
Jaroslav Kočišek
Linda Feketeová
Juraj Fedor
Michal Fárník
Paulo Limão-Vieira
Eugen Illenberger
Stephan Denifl
Low-energy electrons transform the nimorazole molecule into a radiosensitiser
Nature Communications
author_facet Rebecca Meißner
Jaroslav Kočišek
Linda Feketeová
Juraj Fedor
Michal Fárník
Paulo Limão-Vieira
Eugen Illenberger
Stephan Denifl
author_sort Rebecca Meißner
title Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_short Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_full Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_fullStr Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_full_unstemmed Low-energy electrons transform the nimorazole molecule into a radiosensitiser
title_sort low-energy electrons transform the nimorazole molecule into a radiosensitiser
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-06-01
description Radiosensitisers are believed to interfere with cancer cells by dissociating upon interaction with electrons. Here the authors observe instead that the dominant path for nitroimidazolic radiosensitisers involves formation of a non-dissociated radical anion, prerequisite for their accumulation in tumour cells.
url https://doi.org/10.1038/s41467-019-10340-8
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AT jaroslavkocisek lowenergyelectronstransformthenimorazolemoleculeintoaradiosensitiser
AT lindafeketeova lowenergyelectronstransformthenimorazolemoleculeintoaradiosensitiser
AT jurajfedor lowenergyelectronstransformthenimorazolemoleculeintoaradiosensitiser
AT michalfarnik lowenergyelectronstransformthenimorazolemoleculeintoaradiosensitiser
AT paulolimaovieira lowenergyelectronstransformthenimorazolemoleculeintoaradiosensitiser
AT eugenillenberger lowenergyelectronstransformthenimorazolemoleculeintoaradiosensitiser
AT stephandenifl lowenergyelectronstransformthenimorazolemoleculeintoaradiosensitiser
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