Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population

Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member ha...

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Main Authors:	Weihua Meng, Anne E. Hughes, Chris C. Patterson, Christine Belton, Frank Kee, Pascal P. McKeown
Format:	Article
Language:	English
Published:	Hindawi Limited 2008-01-01
Series:	Disease Markers
Online Access:	http://dx.doi.org/10.1155/2008/375617

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spelling	doaj-cd9bbabc1644446fb1ffdf66cf3a5d7b2020-11-24T21:17:16ZengHindawi LimitedDisease Markers0278-02401875-86302008-01-01252818510.1155/2008/375617Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish PopulationWeihua Meng0Anne E. Hughes1Chris C. Patterson2Christine Belton3Frank Kee4Pascal P. McKeown5Centre for Clinical and Population Sciences, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, Northern Ireland, UKCentre for Clinical and Population Sciences, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, Northern Ireland, UKCentre for Clinical and Population Sciences, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, Northern Ireland, UKCentre for Clinical and Population Sciences, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, Northern Ireland, UKCentre for Clinical and Population Sciences, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, Northern Ireland, UKCentre for Clinical and Population Sciences, Queen's University Belfast, Institute of Clinical Science, Grosvenor Road, Belfast, Northern Ireland, UKCoronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 × 10-6, 2.7 × 10-6, 3.8 × 10-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 × 10-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.http://dx.doi.org/10.1155/2008/375617
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Weihua Meng Anne E. Hughes Chris C. Patterson Christine Belton Frank Kee Pascal P. McKeown
spellingShingle	Weihua Meng Anne E. Hughes Chris C. Patterson Christine Belton Frank Kee Pascal P. McKeown Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population Disease Markers
author_facet	Weihua Meng Anne E. Hughes Chris C. Patterson Christine Belton Frank Kee Pascal P. McKeown
author_sort	Weihua Meng
title	Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population
title_short	Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population
title_full	Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population
title_fullStr	Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population
title_full_unstemmed	Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population
title_sort	chromosome 9p21.3 is associated with early-onset coronary heart disease in the irish population
publisher	Hindawi Limited
series	Disease Markers
issn	0278-0240 1875-8630
publishDate	2008-01-01
description	Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males ≤55yr, females ≤60yr) CHD. Genotypes were determined by multiplex SNaPshot technology. Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 × 10-6, 2.7 × 10-6, 3.8 × 10-7, respectively). Analysis of haplotypes by the TRANSMIT program also showed that the GGC haplotype was associated with early-onset CHD (p = 7.9 × 10-7). In conclusion, using a family-based approach in the Irish population, we have confirmed previous reports of association between a region on chromosome 9p21.3 and early-onset CHD.
url	http://dx.doi.org/10.1155/2008/375617
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Chromosome 9p21.3 is Associated with Early-Onset Coronary Heart Disease in the Irish Population

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