New Insights in Thrombin Inhibition Structure–Activity Relationships by Characterization of Octadecasaccharides from Low Molecular Weight Heparin

New Insights in Thrombin Inhibition Structure–Activity Relationships by Characterization of Octadecasaccharides from Low Molecular Weight Heparin

Low Molecular Weight Heparins (LMWH) are complex anticoagulant drugs that mainly inhibit the blood coagulation cascade through indirect interaction with antithrombin. While inhibition of the factor Xa is well described, little is known about the polysaccharide structure inhibiting thrombin. In fact,...

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Bibliographic Details
Main Authors: Pierre A. J. Mourier, Olivier Y. Guichard, Fréderic Herman, Philippe Sizun, Christian Viskov
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Molecules
Subjects:
thrombin inhibition
LMWH
antithrombin
heparin oligosaccharides
ternary complex
Online Access:http://www.mdpi.com/1420-3049/22/3/428

Internet

http://www.mdpi.com/1420-3049/22/3/428

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