Non-linear Optimization of Parameters in Hill Kinetics
A novel least squares optimization of parameters in Hill enzyme kinetics has been developed. The method is based on transformation into “Michaelis-Menten like” type of equation with guaranteed convergence and the initial guess equal to zero. By using this approach, a three parameters non-linear opti...
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Croatian Chemical Society
2016-06-01
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| Series: | Croatica Chemica Acta |
| Online Access: | http://hrcak.srce.hr/file/248246 |
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doaj-cd96c9039e6e4f07b1f67c31ed98b5462020-11-24T23:01:25ZengCroatian Chemical SocietyCroatica Chemica Acta0011-16431334-417X2016-06-0189221321510.5562/cca2863168222Non-linear Optimization of Parameters in Hill KineticsŽeljko Jeričević0Department of Computer Engineering, Technical Faculty, Vukovarska 58, HR-51000 Rijeka, CroatiaA novel least squares optimization of parameters in Hill enzyme kinetics has been developed. The method is based on transformation into “Michaelis-Menten like” type of equation with guaranteed convergence and the initial guess equal to zero. By using this approach, a three parameters non-linear optimization problem is transformed into a one-dimensional search for Hill’s coefficient (exponential parameter <i>n</i>). Numerical experiments illustrating feasibility of the method and quality of the solution are presented. <br><a rel="license" href="http://creativecommons.org/licenses/by/4.0/"><img alt="Creative Commons License" style="border-width:0" src="https://i.creativecommons.org/l/by/4.0/80x15.png" /></a> This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>.http://hrcak.srce.hr/file/248246 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Željko Jeričević |
| spellingShingle |
Željko Jeričević Non-linear Optimization of Parameters in Hill Kinetics Croatica Chemica Acta |
| author_facet |
Željko Jeričević |
| author_sort |
Željko Jeričević |
| title |
Non-linear Optimization of Parameters in Hill Kinetics |
| title_short |
Non-linear Optimization of Parameters in Hill Kinetics |
| title_full |
Non-linear Optimization of Parameters in Hill Kinetics |
| title_fullStr |
Non-linear Optimization of Parameters in Hill Kinetics |
| title_full_unstemmed |
Non-linear Optimization of Parameters in Hill Kinetics |
| title_sort |
non-linear optimization of parameters in hill kinetics |
| publisher |
Croatian Chemical Society |
| series |
Croatica Chemica Acta |
| issn |
0011-1643 1334-417X |
| publishDate |
2016-06-01 |
| description |
A novel least squares optimization of parameters in Hill enzyme kinetics has been developed. The method is based on transformation into “Michaelis-Menten like” type of equation with guaranteed convergence and the initial guess equal to zero. By using this approach, a three parameters non-linear optimization problem is transformed into a one-dimensional search for Hill’s coefficient (exponential parameter <i>n</i>).
Numerical experiments illustrating feasibility of the method and quality of the solution are presented.
<br><a rel="license" href="http://creativecommons.org/licenses/by/4.0/"><img alt="Creative Commons License" style="border-width:0" src="https://i.creativecommons.org/l/by/4.0/80x15.png" /></a> This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>. |
| url |
http://hrcak.srce.hr/file/248246 |
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AT zeljkojericevic nonlinearoptimizationofparametersinhillkinetics |
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1725639534758068224 |