Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter

Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter

The organic mercury compound methylmercury (MeHg) is able to target the fetal brain. However, the uptake of the toxicant into placental cells is incompletely understood. MeHg strongly binds to thiol-S containing molecules such as cysteine. This MeHg-l-cysteine exhibits some structural similarity to...

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Bibliographic Details
Main Authors: Christina Balthasar, Herbert Stangl, Raimund Widhalm, Sebastian Granitzer, Markus Hengstschläger, Claudia Gundacker
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:International Journal of Molecular Sciences
Subjects:
methylmercury
leucine
methionine
human placenta
SLC7A5
SLC7A8
SLC3A2
Forskolin
Online Access:https://www.mdpi.com/1422-0067/18/8/1730

Internet

https://www.mdpi.com/1422-0067/18/8/1730

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