TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs

TRACE: An Unbiased Method to Permanently Tag Transiently Activated Inputs

A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated...

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Bibliographic Details
Main Authors: Nathalie Krauth, Valentina Khalil, Meet Jariwala, Noemie Mermet-Joret, Anne-Katrine Vestergaard, Marco Capogna, Sadegh Nabavi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
neural circuits
optogenetics
viral tracing
innate fear
mouse behavior
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00114/full
Description
Summary:A fundamental interest in circuit analysis is to parse out the synaptic inputs underlying a behavioral experience. Toward this aim, we have devised an unbiased strategy that specifically labels the afferent inputs that are activated by a defined stimulus in an activity-dependent manner. We validated this strategy in four brain circuits receiving known sensory inputs. This strategy, as demonstrated here, accurately identifies these inputs.
ISSN:1662-5102

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