A Comparative Study of Trichomonas Vaginitis Treatment with Single and Seven Day Metronidazole Regimen

• Main Authors: Rafat Bakht, Mitra Modarres Gilani
• Format: Article
• Language: fas
• Published: Hamadan University of Medical Sciences 2003-03-01
• Series: پزشکی بالینی ابن سینا
• Subjects: metronidazole – therapeutic use / vaginal parasit infection-drug therapy
• Online Access: http://sjh.umsha.ac.ir/article-1-781-en.html

Vaginitis is one of the most common genital tract infectious disease and    the major cause of that is trichomonas vaginalis.In this prospective study,    seven day therapeutic regimen was compared with single day therapeutic    regimen and rate of cure and recurrence was accounted.           606 suspected women to trichomoniasis examined with wet mount.    Trichomonas vaginalis was seen in 76 women. Randomisely, women and    their partner were treated with seven day metronidazole (500 mg two times    daily) and single day metronidazole (1 gr morning and evening) regimen.    Every group composed of 38 women. Culture and wet mount was repeated    1 week and 1 month after treatment. Efficacy and recurrence and clinical    cure rate of two regimens were compared.           Two groups were not significantly different in terms of age, weight,    education, follow up and last menstrual period. In the single day group, one    patient missed. By use of Dorsee culture cure rate were 100% in seven day    group and 97.3% in single day group (P=0.87). Recurrence rate were 2.6%    and 5.4% in seven and single day regimens respectively. There were not    significantly statistical difference between two groups (P= 0.5). Occurrence    of side effects were not significantly different between two groups, but    headache was observed in 21.6% and 7.9% of women in single day and    seven day groups respectively.           Single day regimen is recommended as an alternative therapeutic    regimen in trichomoniasis. High efficacy, short therapeutic period and low    cost are advantages of this regimen.