<i>T</i><sub>1</sub>-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule

<i>T</i><sub>1</sub>-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule

To optimize the iron oxide nanoparticles as <i>T</i><sub>1</sub>-weight contrast for in vivo magnetic resonance imaging (MRI), numbers of macromolecule ligands have been explored with considerable effort. However, reports refer to the comparison of the <i>T</i><...

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Main Authors: Cheng Tao, Qiang Zheng, Lu An, Meie He, Jiaomin Lin, Qiwei Tian, Shiping Yang
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Nanomaterials
Subjects:
magnetic resonance imaging
<i>T</i><sub>1</sub>-weight contrasts
magnetic nanoparticles
iron oxide
macromolecule ligands
Online Access:https://www.mdpi.com/2079-4991/9/2/170
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collection DOAJ
language English
format Article
sources DOAJ
author Cheng Tao
Qiang Zheng
Lu An
Meie He
Jiaomin Lin
Qiwei Tian
Shiping Yang
spellingShingle Cheng Tao
Qiang Zheng
Lu An
Meie He
Jiaomin Lin
Qiwei Tian
Shiping Yang
<i>T</i><sub>1</sub>-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule
Nanomaterials
magnetic resonance imaging
<i>T</i><sub>1</sub>-weight contrasts
magnetic nanoparticles
iron oxide
macromolecule ligands
author_facet Cheng Tao
Qiang Zheng
Lu An
Meie He
Jiaomin Lin
Qiwei Tian
Shiping Yang
author_sort Cheng Tao
title <i>T</i><sub>1</sub>-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule
title_short <i>T</i><sub>1</sub>-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule
title_full <i>T</i><sub>1</sub>-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule
title_fullStr <i>T</i><sub>1</sub>-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule
title_full_unstemmed <i>T</i><sub>1</sub>-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial Macromolecule
title_sort <i>t</i><sub>1</sub>-weight magnetic resonance imaging performances of iron oxide nanoparticles modified with a natural protein macromolecule and an artificial macromolecule
publisher MDPI AG
series Nanomaterials
issn 2079-4991
publishDate 2019-01-01
description To optimize the iron oxide nanoparticles as <i>T</i><sub>1</sub>-weight contrast for in vivo magnetic resonance imaging (MRI), numbers of macromolecule ligands have been explored with considerable effort. However, reports refer to the comparison of the <i>T</i><sub>1</sub>-weight contrast performances of iron oxide nanoparticles modified with natural and artificial macromolecule ligands are still limited. In this work, we used a typical natural protein macromolecule (bovine serum albumin, BSA) and an artificial macromolecule (poly(acrylic acid)-poly(methacrylic acid), PMAA-PTTM) as surface ligands to fabricate Fe<sub>3</sub>O<sub>4</sub>-BSA and Fe<sub>3</sub>O<sub>4</sub>-PMAA-PTTM nanoparticles with similar size and magnetization by the coprecipitation method and compared their MRI performances. In vitro and in vivo experiments revealed that Fe<sub>3</sub>O<sub>4</sub>-BSA with lower cytotoxicity exhibited higher <i>r</i><sub>2</sub>/<i>r</i><sub>1</sub> ratio in solution and darkening contrast enhancement for liver and kidney sites of mice under <i>T</i><sub>1</sub>-weight imaging, while Fe<sub>3</sub>O<sub>4</sub>-PMAA-PTTM displayed much lower <i>r</i><sub>2</sub>/<i>r</i><sub>1</sub> ratio in solution and brighter contrast enhancement for liver and kidney sites. These remarkably different MRI behaviors demonstrated that the surface ligands play an important role for optimizing the MRI performance of Fe<sub>3</sub>O<sub>4</sub> nanoparticles. We expect these results may facilitate the design of macromolecule ligands for developing an iron oxide&#8315;based <i>T</i><sub>1</sub>-weight contrast agent.
topic magnetic resonance imaging
<i>T</i><sub>1</sub>-weight contrasts
magnetic nanoparticles
iron oxide
macromolecule ligands
url https://www.mdpi.com/2079-4991/9/2/170
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spelling doaj-cd834ff26edb4356a8ee102d68c6adb62020-11-25T00:27:21ZengMDPI AGNanomaterials2079-49912019-01-019217010.3390/nano9020170nano9020170<i>T</i><sub>1</sub>-Weight Magnetic Resonance Imaging Performances of Iron Oxide Nanoparticles Modified with a Natural Protein Macromolecule and an Artificial MacromoleculeCheng Tao0Qiang Zheng1Lu An2Meie He3Jiaomin Lin4Qiwei Tian5Shiping Yang6The Key Laboratory of Resource Chemistry of the Ministry of Education, the Shanghai Key Laboratory of Rare Earth Functional Materials, and the Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, the Shanghai Key Laboratory of Rare Earth Functional Materials, and the Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, the Shanghai Key Laboratory of Rare Earth Functional Materials, and the Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, the Shanghai Key Laboratory of Rare Earth Functional Materials, and the Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, the Shanghai Key Laboratory of Rare Earth Functional Materials, and the Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, the Shanghai Key Laboratory of Rare Earth Functional Materials, and the Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaThe Key Laboratory of Resource Chemistry of the Ministry of Education, the Shanghai Key Laboratory of Rare Earth Functional Materials, and the Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, ChinaTo optimize the iron oxide nanoparticles as <i>T</i><sub>1</sub>-weight contrast for in vivo magnetic resonance imaging (MRI), numbers of macromolecule ligands have been explored with considerable effort. However, reports refer to the comparison of the <i>T</i><sub>1</sub>-weight contrast performances of iron oxide nanoparticles modified with natural and artificial macromolecule ligands are still limited. In this work, we used a typical natural protein macromolecule (bovine serum albumin, BSA) and an artificial macromolecule (poly(acrylic acid)-poly(methacrylic acid), PMAA-PTTM) as surface ligands to fabricate Fe<sub>3</sub>O<sub>4</sub>-BSA and Fe<sub>3</sub>O<sub>4</sub>-PMAA-PTTM nanoparticles with similar size and magnetization by the coprecipitation method and compared their MRI performances. In vitro and in vivo experiments revealed that Fe<sub>3</sub>O<sub>4</sub>-BSA with lower cytotoxicity exhibited higher <i>r</i><sub>2</sub>/<i>r</i><sub>1</sub> ratio in solution and darkening contrast enhancement for liver and kidney sites of mice under <i>T</i><sub>1</sub>-weight imaging, while Fe<sub>3</sub>O<sub>4</sub>-PMAA-PTTM displayed much lower <i>r</i><sub>2</sub>/<i>r</i><sub>1</sub> ratio in solution and brighter contrast enhancement for liver and kidney sites. These remarkably different MRI behaviors demonstrated that the surface ligands play an important role for optimizing the MRI performance of Fe<sub>3</sub>O<sub>4</sub> nanoparticles. We expect these results may facilitate the design of macromolecule ligands for developing an iron oxide&#8315;based <i>T</i><sub>1</sub>-weight contrast agent.https://www.mdpi.com/2079-4991/9/2/170magnetic resonance imaging<i>T</i><sub>1</sub>-weight contrastsmagnetic nanoparticlesiron oxidemacromolecule ligands

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