Synthesis of new triazole-based trifluoromethyl scaffolds

Synthesis of new triazole-based trifluoromethyl scaffolds

Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus of...

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Bibliographic Details
Main Authors: Michela Martinelli, Thierry Milcent, Sandrine Ongeri, Benoit Crousse
Format: Article
Language:English
Published: Beilstein-Institut 2008-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
copper
catalysis
fluorine
heterocycle
click chemistry
peptidomimetics
Online Access:https://doi.org/10.3762/bjoc.4.19
Description
Summary:Trifluoromethyl propargylamines react with various azide derivatives to afford 1,4-disubstituted 1,2,3-triazoles through a Huisgen 1,3-dipolar cycloaddition. The reaction is catalyzed by a Cu(I) species in acetonitrile, and the corresponding products are obtained in good yields. This process thus offers an entry to new trifluoromethyl peptidomimetics as interesting scaffolds.
ISSN:1860-5397

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