Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature

Renal cell carcinoma is the most common malignancy of the kidney in adults. In children, however, it only accounts for an estimated 1.8 to 6.3% of all pediatric malignant renal tumors. Papillary renal cell carcinoma is the second most common type of renal cell carcinoma in children. We present the c...

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Main Authors: Abelardo Loya-Solis, Lucía Alemán-Meza, Luis Carlos Canales-Martínez, Rodolfo Franco-Márquez, Alim Adriana Rincón-Bahena, Karla María Nuñez-Barragán, Raquel Garza-Guajardo, Marco Antonio Ponce-Camacho
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Case Reports in Pathology
Online Access:http://dx.doi.org/10.1155/2015/841237
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spelling doaj-cd746b30d52e44769545f35d3d04ae2c2020-11-24T22:31:26ZengHindawi LimitedCase Reports in Pathology2090-67812090-679X2015-01-01201510.1155/2015/841237841237Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the LiteratureAbelardo Loya-Solis0Lucía Alemán-Meza1Luis Carlos Canales-Martínez2Rodolfo Franco-Márquez3Alim Adriana Rincón-Bahena4Karla María Nuñez-Barragán5Raquel Garza-Guajardo6Marco Antonio Ponce-Camacho7Pathology Department, Spanish Hospital of Mexico, Ejercito Nacional 613, 11560 Mexico City, DF, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoMedical Imaging Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoRenal cell carcinoma is the most common malignancy of the kidney in adults. In children, however, it only accounts for an estimated 1.8 to 6.3% of all pediatric malignant renal tumors. Papillary renal cell carcinoma is the second most common type of renal cell carcinoma in children. We present the case of a 12-year-old boy with a 2-month history of abdominal pain, unexplained weight loss, and gross hematuria. Computed tomography revealed a horseshoe kidney and a well-defined mass of 4 cm arising from the lower pole of the right kidney. Microscopically the tumor was composed of papillae covered with cells with abundant eosinophilic cytoplasm and high-grade nuclei with prominent nucleoli. Immunohistochemistry was performed; EMA, Vimentin, and AMACR were strongly positive while CK7, CD10, RCC antigen, TFE3, HMB-45, and WT-1 were negative. Currently, 10 months after the surgical procedure, the patient remains clinically and radiologically disease-free.http://dx.doi.org/10.1155/2015/841237
collection DOAJ
language English
format Article
sources DOAJ
author Abelardo Loya-Solis
Lucía Alemán-Meza
Luis Carlos Canales-Martínez
Rodolfo Franco-Márquez
Alim Adriana Rincón-Bahena
Karla María Nuñez-Barragán
Raquel Garza-Guajardo
Marco Antonio Ponce-Camacho
spellingShingle Abelardo Loya-Solis
Lucía Alemán-Meza
Luis Carlos Canales-Martínez
Rodolfo Franco-Márquez
Alim Adriana Rincón-Bahena
Karla María Nuñez-Barragán
Raquel Garza-Guajardo
Marco Antonio Ponce-Camacho
Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature
Case Reports in Pathology
author_facet Abelardo Loya-Solis
Lucía Alemán-Meza
Luis Carlos Canales-Martínez
Rodolfo Franco-Márquez
Alim Adriana Rincón-Bahena
Karla María Nuñez-Barragán
Raquel Garza-Guajardo
Marco Antonio Ponce-Camacho
author_sort Abelardo Loya-Solis
title Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature
title_short Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature
title_full Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature
title_fullStr Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature
title_full_unstemmed Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature
title_sort pediatric papillary renal cell carcinoma in a horseshoe kidney: a case report with review of the literature
publisher Hindawi Limited
series Case Reports in Pathology
issn 2090-6781
2090-679X
publishDate 2015-01-01
description Renal cell carcinoma is the most common malignancy of the kidney in adults. In children, however, it only accounts for an estimated 1.8 to 6.3% of all pediatric malignant renal tumors. Papillary renal cell carcinoma is the second most common type of renal cell carcinoma in children. We present the case of a 12-year-old boy with a 2-month history of abdominal pain, unexplained weight loss, and gross hematuria. Computed tomography revealed a horseshoe kidney and a well-defined mass of 4 cm arising from the lower pole of the right kidney. Microscopically the tumor was composed of papillae covered with cells with abundant eosinophilic cytoplasm and high-grade nuclei with prominent nucleoli. Immunohistochemistry was performed; EMA, Vimentin, and AMACR were strongly positive while CK7, CD10, RCC antigen, TFE3, HMB-45, and WT-1 were negative. Currently, 10 months after the surgical procedure, the patient remains clinically and radiologically disease-free.
url http://dx.doi.org/10.1155/2015/841237
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