Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature
Renal cell carcinoma is the most common malignancy of the kidney in adults. In children, however, it only accounts for an estimated 1.8 to 6.3% of all pediatric malignant renal tumors. Papillary renal cell carcinoma is the second most common type of renal cell carcinoma in children. We present the c...
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doaj-cd746b30d52e44769545f35d3d04ae2c2020-11-24T22:31:26ZengHindawi LimitedCase Reports in Pathology2090-67812090-679X2015-01-01201510.1155/2015/841237841237Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the LiteratureAbelardo Loya-Solis0Lucía Alemán-Meza1Luis Carlos Canales-Martínez2Rodolfo Franco-Márquez3Alim Adriana Rincón-Bahena4Karla María Nuñez-Barragán5Raquel Garza-Guajardo6Marco Antonio Ponce-Camacho7Pathology Department, Spanish Hospital of Mexico, Ejercito Nacional 613, 11560 Mexico City, DF, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoMedical Imaging Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoPathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, MexicoRenal cell carcinoma is the most common malignancy of the kidney in adults. In children, however, it only accounts for an estimated 1.8 to 6.3% of all pediatric malignant renal tumors. Papillary renal cell carcinoma is the second most common type of renal cell carcinoma in children. We present the case of a 12-year-old boy with a 2-month history of abdominal pain, unexplained weight loss, and gross hematuria. Computed tomography revealed a horseshoe kidney and a well-defined mass of 4 cm arising from the lower pole of the right kidney. Microscopically the tumor was composed of papillae covered with cells with abundant eosinophilic cytoplasm and high-grade nuclei with prominent nucleoli. Immunohistochemistry was performed; EMA, Vimentin, and AMACR were strongly positive while CK7, CD10, RCC antigen, TFE3, HMB-45, and WT-1 were negative. Currently, 10 months after the surgical procedure, the patient remains clinically and radiologically disease-free.http://dx.doi.org/10.1155/2015/841237 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Abelardo Loya-Solis Lucía Alemán-Meza Luis Carlos Canales-Martínez Rodolfo Franco-Márquez Alim Adriana Rincón-Bahena Karla María Nuñez-Barragán Raquel Garza-Guajardo Marco Antonio Ponce-Camacho |
spellingShingle |
Abelardo Loya-Solis Lucía Alemán-Meza Luis Carlos Canales-Martínez Rodolfo Franco-Márquez Alim Adriana Rincón-Bahena Karla María Nuñez-Barragán Raquel Garza-Guajardo Marco Antonio Ponce-Camacho Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature Case Reports in Pathology |
author_facet |
Abelardo Loya-Solis Lucía Alemán-Meza Luis Carlos Canales-Martínez Rodolfo Franco-Márquez Alim Adriana Rincón-Bahena Karla María Nuñez-Barragán Raquel Garza-Guajardo Marco Antonio Ponce-Camacho |
author_sort |
Abelardo Loya-Solis |
title |
Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature |
title_short |
Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature |
title_full |
Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature |
title_fullStr |
Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature |
title_full_unstemmed |
Pediatric Papillary Renal Cell Carcinoma in a Horseshoe Kidney: A Case Report with Review of the Literature |
title_sort |
pediatric papillary renal cell carcinoma in a horseshoe kidney: a case report with review of the literature |
publisher |
Hindawi Limited |
series |
Case Reports in Pathology |
issn |
2090-6781 2090-679X |
publishDate |
2015-01-01 |
description |
Renal cell carcinoma is the most common malignancy of the kidney in adults. In children, however, it only accounts for an estimated 1.8 to 6.3% of all pediatric malignant renal tumors. Papillary renal cell carcinoma is the second most common type of renal cell carcinoma in children. We present the case of a 12-year-old boy with a 2-month history of abdominal pain, unexplained weight loss, and gross hematuria. Computed tomography revealed a horseshoe kidney and a well-defined mass of 4 cm arising from the lower pole of the right kidney. Microscopically the tumor was composed of papillae covered with cells with abundant eosinophilic cytoplasm and high-grade nuclei with prominent nucleoli. Immunohistochemistry was performed; EMA, Vimentin, and AMACR were strongly positive while CK7, CD10, RCC antigen, TFE3, HMB-45, and WT-1 were negative. Currently, 10 months after the surgical procedure, the patient remains clinically and radiologically disease-free. |
url |
http://dx.doi.org/10.1155/2015/841237 |
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