Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks

Microbial rhodopsins can be used to control action potentials, while animal opsins can be used to control intracellular signaling pathways. The authors identify Opn7b as constitutively active Gi/o coupled receptor that can be deactivated by light and used to modulate neuronal activity.

Bibliographic Details
Main Authors:	Raziye Karapinar, Jan Claudius Schwitalla, Dennis Eickelbeck, Johanna Pakusch, Brix Mücher, Michelle Grömmke, Tatjana Surdin, Thomas Knöpfel, Melanie D. Mark, Ida Siveke, Stefan Herlitze
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-24718-0

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spelling	doaj-cd6b728c8c2a41f6902c7cf1ab408a532021-07-25T11:38:58ZengNature Publishing GroupNature Communications2041-17232021-07-0112111410.1038/s41467-021-24718-0Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networksRaziye Karapinar0Jan Claudius Schwitalla1Dennis Eickelbeck2Johanna Pakusch3Brix Mücher4Michelle Grömmke5Tatjana Surdin6Thomas Knöpfel7Melanie D. Mark8Ida Siveke9Stefan Herlitze10Department of Zoology and Neurobiology, Ruhr-University BochumBehavioral Neuroscience, Ruhr-University BochumDepartment of Zoology and Neurobiology, Ruhr-University BochumBehavioral Neuroscience, Ruhr-University BochumDepartment of Zoology and Neurobiology, Ruhr-University BochumBehavioral Neuroscience, Ruhr-University BochumDepartment of Zoology and Neurobiology, Ruhr-University BochumLaboratory of Optogenetics and Circuit Neuroscience, Imperial College LondonBehavioral Neuroscience, Ruhr-University BochumDepartment of Zoology and Neurobiology, Ruhr-University BochumDepartment of Zoology and Neurobiology, Ruhr-University BochumMicrobial rhodopsins can be used to control action potentials, while animal opsins can be used to control intracellular signaling pathways. The authors identify Opn7b as constitutively active Gi/o coupled receptor that can be deactivated by light and used to modulate neuronal activity.https://doi.org/10.1038/s41467-021-24718-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Raziye Karapinar Jan Claudius Schwitalla Dennis Eickelbeck Johanna Pakusch Brix Mücher Michelle Grömmke Tatjana Surdin Thomas Knöpfel Melanie D. Mark Ida Siveke Stefan Herlitze
spellingShingle	Raziye Karapinar Jan Claudius Schwitalla Dennis Eickelbeck Johanna Pakusch Brix Mücher Michelle Grömmke Tatjana Surdin Thomas Knöpfel Melanie D. Mark Ida Siveke Stefan Herlitze Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks Nature Communications
author_facet	Raziye Karapinar Jan Claudius Schwitalla Dennis Eickelbeck Johanna Pakusch Brix Mücher Michelle Grömmke Tatjana Surdin Thomas Knöpfel Melanie D. Mark Ida Siveke Stefan Herlitze
author_sort	Raziye Karapinar
title	Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks
title_short	Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks
title_full	Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks
title_fullStr	Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks
title_full_unstemmed	Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks
title_sort	reverse optogenetics of g protein signaling by zebrafish non-visual opsin opn7b for synchronization of neuronal networks
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-07-01
description	Microbial rhodopsins can be used to control action potentials, while animal opsins can be used to control intracellular signaling pathways. The authors identify Opn7b as constitutively active Gi/o coupled receptor that can be deactivated by light and used to modulate neuronal activity.
url	https://doi.org/10.1038/s41467-021-24718-0
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Reverse optogenetics of G protein signaling by zebrafish non-visual opsin Opn7b for synchronization of neuronal networks

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