Tyrosinase Overexpression Promotes ATM-Dependent p53 Phosphorylation by Quercetin and Sensitizes Melanoma Cells to Dacarbazine

Dacarbazine (DTIC) has been used for the treatment of melanoma for decades. However, monotherapy with this chemotherapeutic agent results only in moderate response rates. To improve tumor response to DTIC current clinical trials in melanoma focus on combining a novel targeted agent with chemotherapy...

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Bibliographic Details
Main Authors: Thilakavathy Thangasamy, Sivanandane Sittadjody, Kirsten H. Limesand, Randy Burd
Format: Article
Language:English
Published: Hindawi Limited 2008-01-01
Series:Cellular Oncology
Online Access:http://dx.doi.org/10.3233/CLO-2008-0441

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