AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

Abstract Background Mesenchymal stromal cell (MSC) stemness capacity diminishes over prolonged in vitro culture, which negatively affects their application in regenerative medicine. To slow down the senescence of MSCs, here, we have evaluated the in vitro effects of 5-aminoimidazole-4-carboxamide ri...

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Bibliographic Details
Main Authors: Mohammadhossein Khorraminejad-Shirazi, Mahsa Sani, Tahereh Talaei-Khozani, Mohammadreza Dorvash, Malihe Mirzaei, Mohammad Ali Faghihi, Ahmad Monabati, Armin Attar
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Stem Cell Research & Therapy
Subjects:
mTOR
AMPK
SIRT1
Autophagy
Senescence
AICAR
Online Access:https://doi.org/10.1186/s13287-020-1565-6

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