The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

The relationship between synaptic density marker SV2A, glutamate and N-acetyl aspartate levels in healthy volunteers and schizophrenia: a multimodal PET and magnetic resonance spectroscopy brain imaging study

Abstract Glutamatergic excitotoxicity is hypothesised to underlie synaptic loss in schizophrenia pathogenesis, but it is unknown whether synaptic markers are related to glutamatergic function in vivo. Additionally, it has been proposed that N-acetyl aspartate (NAA) levels reflect neuronal integrity....

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Bibliographic Details
Main Authors: Ellis Chika Onwordi, Thomas Whitehurst, Ayla Mansur, Ben Statton, Alaine Berry, Marina Quinlan, Declan P. O’Regan, Maria Rogdaki, Tiago Reis Marques, Eugenii A. Rabiner, Roger N. Gunn, Anthony C. Vernon, Sridhar Natesan, Oliver D. Howes
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01515-3

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