Novel Insight Into the Molecular and Metabolic Mechanisms Orchestrating IL-17 Production in γδ T Cells
Increasing evidence has demonstrated that IL-17-producing γδ T cells (γδ T17) play a tumor-promoting role in a series of cancers via various mechanisms in mice and human cancers, though the relationship between γδ T17 and human tumors has yet to be extensively characterized and established. Molecula...
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Frontiers Media S.A.
2019-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02828/full |
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doaj-cd4b3690b39a4d7fa88e32286cb8db6c2020-11-25T01:35:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-12-011010.3389/fimmu.2019.02828498817Novel Insight Into the Molecular and Metabolic Mechanisms Orchestrating IL-17 Production in γδ T CellsXu Chen0Xu Chen1Samantha Morrissey2Samantha Morrissey3Fuxiang Chen4Fuxiang Chen5Jun Yan6Department of Clinical Immunology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaImmuno-Oncology Program, Division of Immunotherapy, Department of Surgery, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, United StatesImmuno-Oncology Program, Division of Immunotherapy, Department of Surgery, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, United StatesDepartment of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, United StatesDepartment of Clinical Immunology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaFaculty of Medical Labratory Science, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaImmuno-Oncology Program, Division of Immunotherapy, Department of Surgery, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, United StatesIncreasing evidence has demonstrated that IL-17-producing γδ T cells (γδ T17) play a tumor-promoting role in a series of cancers via various mechanisms in mice and human cancers, though the relationship between γδ T17 and human tumors has yet to be extensively characterized and established. Molecular signals such as intrinsic cascade, environmental cues and cellular metabolic pathways including nutrient uptake and utilization in γδ T17 cells are significantly important for their activation, differentiation, and function. Understanding the molecular mechanisms and metabolic pathways of γδ T17 cells in both the physiological setting and tumor environment would contribute to the development of therapeutic approaches or drugs targeting γδ T17 for immunotherapy in cancers.https://www.frontiersin.org/article/10.3389/fimmu.2019.02828/fullinnate immune cellsγδ T17 cellstranscriptional regulationmetabolic reprogrammingcancer immunotherapy |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xu Chen Xu Chen Samantha Morrissey Samantha Morrissey Fuxiang Chen Fuxiang Chen Jun Yan |
| spellingShingle |
Xu Chen Xu Chen Samantha Morrissey Samantha Morrissey Fuxiang Chen Fuxiang Chen Jun Yan Novel Insight Into the Molecular and Metabolic Mechanisms Orchestrating IL-17 Production in γδ T Cells Frontiers in Immunology innate immune cells γδ T17 cells transcriptional regulation metabolic reprogramming cancer immunotherapy |
| author_facet |
Xu Chen Xu Chen Samantha Morrissey Samantha Morrissey Fuxiang Chen Fuxiang Chen Jun Yan |
| author_sort |
Xu Chen |
| title |
Novel Insight Into the Molecular and Metabolic Mechanisms Orchestrating IL-17 Production in γδ T Cells |
| title_short |
Novel Insight Into the Molecular and Metabolic Mechanisms Orchestrating IL-17 Production in γδ T Cells |
| title_full |
Novel Insight Into the Molecular and Metabolic Mechanisms Orchestrating IL-17 Production in γδ T Cells |
| title_fullStr |
Novel Insight Into the Molecular and Metabolic Mechanisms Orchestrating IL-17 Production in γδ T Cells |
| title_full_unstemmed |
Novel Insight Into the Molecular and Metabolic Mechanisms Orchestrating IL-17 Production in γδ T Cells |
| title_sort |
novel insight into the molecular and metabolic mechanisms orchestrating il-17 production in γδ t cells |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Immunology |
| issn |
1664-3224 |
| publishDate |
2019-12-01 |
| description |
Increasing evidence has demonstrated that IL-17-producing γδ T cells (γδ T17) play a tumor-promoting role in a series of cancers via various mechanisms in mice and human cancers, though the relationship between γδ T17 and human tumors has yet to be extensively characterized and established. Molecular signals such as intrinsic cascade, environmental cues and cellular metabolic pathways including nutrient uptake and utilization in γδ T17 cells are significantly important for their activation, differentiation, and function. Understanding the molecular mechanisms and metabolic pathways of γδ T17 cells in both the physiological setting and tumor environment would contribute to the development of therapeutic approaches or drugs targeting γδ T17 for immunotherapy in cancers. |
| topic |
innate immune cells γδ T17 cells transcriptional regulation metabolic reprogramming cancer immunotherapy |
| url |
https://www.frontiersin.org/article/10.3389/fimmu.2019.02828/full |
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