The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate

This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the “Warburg” and “Crabtree” effects. This work also summarizes two key discoveries, one of which relates to hexokinase-2 (HK2), a major player in both the “Warburg effect” and canc...

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Bibliographic Details
Main Authors: Paweł Lis, Mariusz Dyląg, Katarzyna Niedźwiecka, Young H. Ko, Peter L. Pedersen, Andre Goffeau, Stanisław Ułaszewski
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Molecules
Subjects:
3-bromopyruvate
antitumor therapy
Warburg effect
Crabtree effect
oxidative phosphorylation
glutathione
buthionine sulphoximine
Online Access:http://www.mdpi.com/1420-3049/21/12/1730

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