Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward

Prolonged Persistence of Chimeric Antigen Receptor (CAR) T Cell in Adoptive Cancer Immunotherapy: Challenges and Ways Forward

CAR T cell qualities, such as persistence and functionality play important roles in determining the outcome of cancer immunotherapy. In spite of full functionality, it has been shown that poor persistence of CAR T cells can limit an effective antitumor immune response. Here, we outline specific stra...

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Bibliographic Details
Main Authors: Leila Jafarzadeh, Elham Masoumi, Keyvan Fallah-Mehrjardi, Hamid Reza Mirzaei, Jamshid Hadjati
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor
T cells
persistence
tumor microenvironment
cancer immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00702/full

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