Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex
Development of a novel antioxidant-delivery vehicle exerting biosafety has been attracting a great deal of interest. In this study, a vehicle comprising a natural composite consisting of vitamin E (α-tocopherol; Toc) and cyclodextrin (CD) additives was developed, directed toward aqua-related biologi...
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MDPI AG
2021-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/3/490 |
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doaj-cd39da83686646f2b5702698365501a82021-03-21T00:02:56ZengMDPI AGAntioxidants2076-39212021-03-011049049010.3390/antiox10030490Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E ComplexShigesaburo Ogawa0Mai Shinkawa1Ryuji Hirase2Taro Tsubomura3Katsuya Iuchi4Setsuko Hara5Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo 180-8633, JapanDepartment of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo 180-8633, JapanHyogo Prefectural Institute of Technology, 3-1-12 Yukihira-cho, Suma, Kobe 654-0037, JapanDepartment of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo 180-8633, JapanDepartment of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo 180-8633, JapanDepartment of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo 180-8633, JapanDevelopment of a novel antioxidant-delivery vehicle exerting biosafety has been attracting a great deal of interest. In this study, a vehicle comprising a natural composite consisting of vitamin E (α-tocopherol; Toc) and cyclodextrin (CD) additives was developed, directed toward aqua-related biological applications. Not only <i>β</i>-CD, but also <i>γ</i>-CD, tended to form a water-insoluble aggregate with Toc in aqueous media. The aggregated vehicle, in particular the <i>γ</i>-CD-added system, showed a remarkable sustained effect because of slow dynamics. Furthermore, a prominent cytoprotective effect by the <i>γ</i>-CD–Toc vehicle under the oxidative stress condition was confirmed. Thus, the novel vitamin E vehicle motif using <i>γ</i>-CD as a stabilizer was proposed, widening the usability of Toc for biological applications.https://www.mdpi.com/2076-3921/10/3/490vitamin E<i>γ</i>-cyclodextrinvehicleradical scavengingoxidative stresscell viability |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shigesaburo Ogawa Mai Shinkawa Ryuji Hirase Taro Tsubomura Katsuya Iuchi Setsuko Hara |
| spellingShingle |
Shigesaburo Ogawa Mai Shinkawa Ryuji Hirase Taro Tsubomura Katsuya Iuchi Setsuko Hara Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex Antioxidants vitamin E <i>γ</i>-cyclodextrin vehicle radical scavenging oxidative stress cell viability |
| author_facet |
Shigesaburo Ogawa Mai Shinkawa Ryuji Hirase Taro Tsubomura Katsuya Iuchi Setsuko Hara |
| author_sort |
Shigesaburo Ogawa |
| title |
Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex |
| title_short |
Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex |
| title_full |
Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex |
| title_fullStr |
Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex |
| title_full_unstemmed |
Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex |
| title_sort |
development of water-insoluble vehicle comprising natural cyclodextrin—vitamin e complex |
| publisher |
MDPI AG |
| series |
Antioxidants |
| issn |
2076-3921 |
| publishDate |
2021-03-01 |
| description |
Development of a novel antioxidant-delivery vehicle exerting biosafety has been attracting a great deal of interest. In this study, a vehicle comprising a natural composite consisting of vitamin E (α-tocopherol; Toc) and cyclodextrin (CD) additives was developed, directed toward aqua-related biological applications. Not only <i>β</i>-CD, but also <i>γ</i>-CD, tended to form a water-insoluble aggregate with Toc in aqueous media. The aggregated vehicle, in particular the <i>γ</i>-CD-added system, showed a remarkable sustained effect because of slow dynamics. Furthermore, a prominent cytoprotective effect by the <i>γ</i>-CD–Toc vehicle under the oxidative stress condition was confirmed. Thus, the novel vitamin E vehicle motif using <i>γ</i>-CD as a stabilizer was proposed, widening the usability of Toc for biological applications. |
| topic |
vitamin E <i>γ</i>-cyclodextrin vehicle radical scavenging oxidative stress cell viability |
| url |
https://www.mdpi.com/2076-3921/10/3/490 |
| work_keys_str_mv |
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