The effect of the continuous aerobic and high-intensity interval training on IRS1 gene expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus

• Main Authors: Bahmani M, Piri M, Azarbayjani MA, Matinhomaee H
• Format: Article
• Language: fas
• Published: Kashan University of Medical Sciences and Health Services 2020-07-01
• Series: Fiyz̤
• Subjects: aerobic continuous exercise; hiit; type 2 diabetes; irs1 gene
• Online Access: http://feyz.kaums.ac.ir/article-1-4011-en.html

Background: Physical activity has been recognized, as an effective way to prevent and treat diabetes. This study aimed to determine the effect of the continuous aerobic - versus high -intensity interval training on IRS1 gene expression and its correlation with insulin resistance index in liver tissue with type 2 diabetic rats. Materials and Methods: In an experimental study, 24 male Wistar rats aged 6-5 weeks weighed 160 to 180 g. The rats were randomly divided into three groups of 8 controls, aerobic continuity, and severe periodicity. Each group performed their protocol five days a week for eight weeks. 24 hours after the last training session, blood samples were collected directly from heart of rats. The liver tissue was immediately extracted. Pearson correlation, one-way ANOVA and Tukey post hoc test were used to analyze the data. Results: The results of this research showed that both trainings had a significant effect on the expression of IRS1 gene in the liver of type 2 diabetes mellitus than in the control group (P=0.011), but no difference was observed in the two training groups (P=0.874). There was a significant correlation between IRS1 gene expression and insulin resistance index in the liver of type 2 diabetic rats after a HIIT and continuous exercise (P=-0.634). Increasing the IRS1 gene, reduced the insulin resistance index (r= -0.634, P=0.005). Conclusion: It seems that both intensive and continuous aerobic exercises could be used to improve the indices studied in subjects with type 2 diabetes.