Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance

Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance

The canonical hedgehog (HH) pathway is a multicomponent signaling cascade (HH, protein patched homolog 1 (PTCH1), smoothened (SMO)) that plays a pivotal role during embryonic development through activation of downstream effector molecules, namely glioma-associated oncogene homolog 1 (GLI1), GLI2 and...

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Bibliographic Details
Main Authors: Komaraiah Palle, Chinnadurai Mani, Kaushlendra Tripathi, Mohammad Athar
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Cancers
Subjects:
hedgehog signaling
GLI1
DNA damage
carcinogenesis
chemoresistance
Online Access:http://www.mdpi.com/2072-6694/7/4/0894

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